GrandMother Eloise is a rich old woman worth 80 million and everybody in the family is always trying to get into her will.
We know her from one episode where she descends upon the Sheffield home to check if Maxwell, her grandson is fit to be in her Will.
It reveals that Eloise bonds very nicely with C.C. and asks her if she is 'single by choice' but with Niles
Although it is unknown whether she cut him out of the Will or not, in the last few minutes of the episode it reveals that she gets along very well with GrandMa Yetta who wrongly informs her that Mr. Sheffield and Fran have been married for three years 'already' and they 'got' teenage kids.